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KMID : 0606920200280010074
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Biomolecules & Therapeutics
2020 Volume.28 No. 1 p.74 ~ p.82
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β-Amyrin Ameliorates Alzheimer’s Disease-Like Aberrant Synaptic Plasticity in the Mouse Hippocampus
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Park Hye-Jin
Kwon Hui-Young
Lee Ji-Hye
Cho Eun-Bi
Lee Young-Choon
Moon Min-Ho
Jun Mi-Ra
Kim Dong-Hyun
Jung Ji-Wook
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Abstract
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Alzheimer’s disease (AD) is a progressive and most frequently diagnosed neurodegenerative disorder. However, there is still no drug preventing the progress of this disorder. β-Amyrin, an ingredient of the surface wax of tomato fruit and dandelion coffee, is previously reported to ameliorate memory impairment induced by cholinergic dysfunction. Therefore, we tested whether β-amyrin can prevent AD-like pathology. β-Amyrin blocked amyloid β (Aβ)-induced long-term potentiation (LTP) impairment in the hippocampal slices. Moreover, β-amyrin improved Aβ-induced suppression of phosphatidylinositol-3-kinase (PI3K)/Akt signaling. LY294002, a PI3K inhibitor, blocked the effect of β-amyrin on Aβ-induced LTP impairment. In in vivo experiments, we observed that β-amyrin ameliorated object recognition memory deficit in Aβ-injected AD mice model. Moreover, neurogenesis impairments induced by Aβ was improved by β-amyrin treatment. Taken together, β-amyrin might be a good candidate of treatment or supplement for AD patients.
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KEYWORD
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β-amyrin, Amyloid β, Alzheimer’s disease, Synaptic plasticity
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